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Semax 10mg

Semax 10mg — research compound vial

A research-stable neuropeptide derived from a naturally occurring brain signaling molecule. Registered for medical use in Russia and extensively studied for its influence on key neurological pathways and brain health markers.

10mg
$44

How It Works

The Target

BDNF (Brain-Derived Neurotrophic Factor) production in the hippocampus and basal forebrain. Semax is a synthetic analogue of ACTH(4-10) with a stabilizing Pro-Gly-Pro extension.

The Mechanism

Upregulates BDNF mRNA and protein expression — BDNF is the primary growth factor for neuronal survival, synaptic plasticity, and new neural connections. Also activates dopaminergic and serotonergic systems and modulates immune gene expression in the brain during ischemic conditions.

Why It Matters

The Pro-Gly-Pro extension makes Semax resistant to enzymatic breakdown, giving it a longer activity window. It is approved in Russia for cognitive and neuroprotective applications, with multiple published studies on BDNF upregulation.

Specifications

Purity>=98%
MW~863 Da
FormLyophilized white powder
Storage-20 degrees C
ReconstitutionSterile saline
Shelf Life24 months

Published References

review
Modulation of neuropathological pathways by bioactive peptides and proteins/polypeptides: Targeting oxidative stress in neurodegenerative diseases (Neuropeptides 2025) ↗
peer
Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress (European journal of pharmacology 2024) ↗
peer
The Potential of the Peptide Drug Semax and Its Derivative for Correcting Pathological Impairments in the Animal Model of Alzheimer's Disease (Acta Naturae 2025) ↗
peer
Investigation of the effect of a modified fragment of neuropeptide Y on memory phases and extrapolation escape of animals (Ceska a Slovenska farmacie : casopis ... 2021) ↗
peer
The Effect of Peptide Semax, an ACTH(4-10) Analogue, on Intracellular Calcium Dynamics in Rat Brain Neurons (Bull Exp Biol Med 2025) ↗

Read the full Semax vs Selank research article →

Semax 10mg

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Research Use Only. Semax 10mg is sold exclusively for in vitro laboratory research. It is not a drug, dietary supplement, food, or medical device, and has not been evaluated by the FDA for any purpose. Not for human or veterinary use. NST Research makes no therapeutic, diagnostic, or health claims regarding any compound listed.