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Metabolic

Retatrutide 30mg

Retatrutide 30mg — research compound vial

Currently in Phase III clinical trials — the most advanced metabolic research compound of its kind. Retatrutide targets three receptor systems simultaneously, a first-of-its-kind approach that produced significant results in published Phase II data.

30mg
$99

How It Works

The Target

Three metabolic receptors simultaneously: GLP-1, GIP, and Glucagon. This triple-agonist approach is unique — most compounds target only one or two.

The Mechanism

GLP-1 activation enhances insulin release when blood sugar is elevated. GIP amplifies this effect and influences fat storage signaling. Glucagon receptor activation increases energy expenditure and fat oxidation in the liver. Together, they create a coordinated metabolic response across multiple organ systems.

Why It Matters

Phase II trials showed the triple mechanism produced significantly greater effects than single or dual agonists alone, suggesting the three pathways work synergistically rather than just additively.

Specifications

Purity>=98% (HPLC)
MW~4.8 kDa
FormLyophilized white powder
Storage-20 degrees C, protect from light
ReconstitutionBacteriostatic water
Shelf Life24 months lyophilized

Published References

clinical
Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial (Nature medicine 2024) ↗
clinical
Effects of retatrutide on body composition in people with type 2 diabetes: a substudy of a phase 2, double-blind, parallel-group, placebo-controlled, randomised trial (The lancet. Diabetes & endocrinology 2025) ↗
clinical
Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA (Lancet (London, England) 2023) ↗
review
Gut hormones and appetite regulation (Current opinion in endocrinology, dia... 2024) ↗
review
Emerging pharmacotherapies for obesity: A systematic review (Pharmacological reviews 2025) ↗
review
Seven glucagon-like peptide-1 receptor agonists and polyagonists for weight loss in patients with obesity or overweight: an updated systematic review and network meta-analysis of randomized controlled trials (Metabolism: clinical and experimental 2024) ↗

Retatrutide 30mg

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Research Use Only. Retatrutide 30mg is sold exclusively for in vitro laboratory research. It is not a drug, dietary supplement, food, or medical device, and has not been evaluated by the FDA for any purpose. Not for human or veterinary use. NST Research makes no therapeutic, diagnostic, or health claims regarding any compound listed.