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Endocrine

HCG 5000iu

HCG 5000iu — research compound vial

A well-characterized glycoprotein hormone with multiple FDA-approved medical uses. Used as a standard reference compound in reproductive and endocrine research for decades, with one of the most established safety profiles in the field.

5000iu
$28

How It Works

The Target

LH/hCG receptors (LHCGR) primarily on Leydig cells in the testes and granulosa cells in the ovaries. hCG is a naturally occurring glycoprotein hormone produced during pregnancy.

The Mechanism

Mimics luteinizing hormone (LH) at its receptor, triggering the same downstream cascade: Gs protein activation, cAMP production, PKA signaling, and ultimately steroidogenesis. In males, this stimulates testosterone production. In females, it triggers ovulation and supports corpus luteum function.

Why It Matters

Multiple FDA-approved medical uses with decades of clinical data. In research contexts, hCG is used to maintain intratesticular testosterone during exogenous hormone administration, preserving spermatogenesis and testicular function.

Specifications

FormLyophilized white powder
Storage2-8 degrees C; -20 degrees C long-term
ReconstitutionBacteriostatic water
Shelf Life18 months
Potency5000 IU/vial

Published References

review
Molecular Crosstalk Between Intrauterine hCG and Endometrial Receptivity: Signalling Pathways, Immune Modulation, and Translational Perspectives in IVF (International journal of molecular sc... 2025) ↗
review
Hormonal and Allosteric Regulation of the Luteinizing Hormone/Chorionic Gonadotropin Receptor (Frontiers in bioscience (Landmark edi... 2024) ↗
review
Dual trigger improves the pregnancy rate in fresh in vitro fertilization (IVF) cycles compared with the human chorionic gonadotropin (hCG) trigger: a systematic review and meta-analysis of randomized trials (Journal of assisted reproduction and ... 2023) ↗
peer
Reading the hCG tea leaves (F&S reports 2025) ↗
review
Research Progress on the Impact of Human Chorionic Gonadotropin on Reproductive Performance in Sows (Animals : an open access journal from... 2024) ↗
peer
Optimal restoration of spermatogenesis after testosterone therapy using human chorionic gonadotropin and follicle-stimulating hormone (Fertility and sterility 2025) ↗

HCG 5000iu

Third-party verified · batch COAs · US-based fulfillment

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Research Use Only. HCG 5000iu is sold exclusively for in vitro laboratory research. It is not a drug, dietary supplement, food, or medical device, and has not been evaluated by the FDA for any purpose. Not for human or veterinary use. NST Research makes no therapeutic, diagnostic, or health claims regarding any compound listed.