5-Amino-1MQ
A small-molecule research compound studied for its role in cellular metabolism and the NAD+ pathway. Examined in laboratory models for its influence on how fat cells process and store energy.
Read the full 5-Amino-1MQ research overview — NNMT, NAD+ & the published studies →
How It Works
The Target
NNMT (Nicotinamide N-methyltransferase) — an enzyme that diverts nicotinamide away from NAD+ production. NNMT is overexpressed in fat tissue of obese individuals.
The Mechanism
By blocking NNMT, more nicotinamide is available to produce NAD+ — a critical coenzyme for cellular energy metabolism. Higher NAD+ levels activate sirtuins and boost mitochondrial function in fat cells, shifting them from energy storage toward energy expenditure.
Why It Matters
Preclinical studies showed NNMT inhibition reversed diet-induced obesity in mice without changing food intake, suggesting the metabolic shift alone can drive changes in body composition.
Specifications
| Purity | >=98% |
| MW | ~187 Da |
| Form | Powder (10mg vial) or oral tablet (30mg, 120 ct) |
| Storage | -20 degrees C (powder); cool, dry (tablet) |
| Reconstitution | DMSO / ethanol (powder); none for tablet |
| Shelf Life | 24 months |